Visual pathway demyelination in neurofascin-155 IGG4- positive combined central and peripheral demyelination

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منابع مشابه

Neurofascin-155 as a putative antigen in combined central and peripheral demyelination

Combined central and peripheral demyelination (CCPD) encompasses a wide array of disorders ranging from myeloradiculoneuritis and encephalomyeloradiculoneuritis, which often occur after infection or vaccination, to co-occurrence of multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Antibodies directed to neurofascin-155 (NF155), a protein expressed in ...

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Combined Central and Peripheral Demyelination.

Demyelinating disorders are very common, but remains isolated to the part of nervous system they involve. However, infrequently, combined involvement of central and peripheral nervous system with demyelinating process have been described. We report one such rare case, with possible theories of common etiological basis. We present a middle aged male patient with Chronic Inflammatory Demyelinatin...

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Anti-neurofascin antibody in patients with combined central and peripheral demyelination.

OBJECTIVES We aimed to identify the target antigens for combined central and peripheral demyelination (CCPD). METHODS We screened target antigens by immunohistochemistry and immunoblotting using peripheral nerve tissues to identify target antigens recognized by serum antibodies from selected CCPD and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) cases. We then measured the ...

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Characterization of IgG4 anti-neurofascin 155 antibody-positive polyneuropathy

OBJECTIVE To investigate anti-neurofascin 155 (NF155) antibody-positive chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS Sera from 50 consecutive CIDP patients diagnosed in our clinic, 32 patients with multiple sclerosis, 40 patients with other neuropathies including 26 with Guillain-Barré syndrome (GBS)/Fisher syndrome, and 30 healthy controls were measured for anti-NF antib...

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Abnormal evoked potentials in Miller-Fisher syndrome: further evidence of combined peripheral and central demyelination.

1 Tsuji I, Nakajima F, Morimoto J, Nounaka Y. The sexual function in patients with spinal cord injury. Urol Int 196 1;12:270-80. 2 Brindley GS. The actions of parasympathetic and sympathetic nerves in human micturition, erection and seminal emission and their restoration in paraplegic patients by implanted electrical stimulators. Proc R Soc Lond 1988;B235: 111-20. 3 Yeates WK. Ejaculation and i...

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ژورنال

عنوان ژورنال: Journal of the Neurological Sciences

سال: 2019

ISSN: 0022-510X

DOI: 10.1016/j.jns.2019.10.1159